Journal: Frontiers in Physiology

Article Title: Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring

doi: 10.3389/fphys.2022.931147

Figure Lengend Snippet: Examples of the signals studied. (A) Mean photopic 3.0 cd s m −2 fERG from all subjects. (B) Mean scotopic 0.005 cd s m −2 fERG (pure-rod) from all subjects. (C) Mean scotopic 1.0 cd s m −2 fERG (mixed rod-cone) from all subjects. (D) Single sample of a photopic rsERG with 30 cd m −2 white background. (E) Single sample of an EEG (forehead electrode) with 30 cd m −2 white background. (F) Single sample from electrode in saline with 30 cd m −2 white background (amplified 4 times; blue signal matches blue calibration bar). Red arrows in (A–C) show flash onset.

Article Snippet: The background light intensities used were of 0, 1, 20 and 30 cd m −2 (white light) in light-adapted conditions, and of 0, 0.0005, 0.001, 0.005, 0.05, and 1 cd m −2 (Rod-color light from Diagnosys LLC, Lowell, MA, made from the green and blue LEDs) in dark-adapted conditions.

Techniques: Saline, Amplification

Journal: Frontiers in Physiology

Article Title: Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring

doi: 10.3389/fphys.2022.931147

Figure Lengend Snippet: Comparing rsERGs at background light colors. Mean frequency spectrums of rsERGs obtained from different colored background lights at 30 cd m −2 , i.e., black (no illumination; black tracings), white (yellow tracings), red (red tracings), green (green tracings) and blue (blue tracings). (A) Original mean frequency spectrums in log-log scale. Of note, the vertical dotted line shows the upper limit of data points used in the linear regression, i.e., data points from 7 Hz to 275 Hz. (B) Modified spectrums (zoomed) in log-log scale, with the 1 / f α background activity removed. (C,D) Multifractal analysis on the colored rsERG signals. (C) Values ± STD of the main exponent H m . (D) Values ± STD of the dispersion index D .

Article Snippet: The background light intensities used were of 0, 1, 20 and 30 cd m −2 (white light) in light-adapted conditions, and of 0, 0.0005, 0.001, 0.005, 0.05, and 1 cd m −2 (Rod-color light from Diagnosys LLC, Lowell, MA, made from the green and blue LEDs) in dark-adapted conditions.

Techniques: Modification, Activity Assay, Dispersion

Journal: Frontiers in Physiology

Article Title: Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring

doi: 10.3389/fphys.2022.931147

Figure Lengend Snippet: Pathological cases and the rsERG. Examples of pathological cases (blue traces) compared to normal subjects (black traces). Row (A) shows examples of normal data, while each subsequent row (B–F) shows a different patient. The first column ( I ) shows the ISCEV standard photopic fERG (flash: 3 cd s m −2 , background light: 30 cd m −2 ) recordings, with the associated frequency spectrums shown in the second column ( II ). The light-adapted 30 cd m −2 white background light rsERG frequency spectrums are shown in the third column ( III ), with the normal subject mean ± standard deviations shown in black dashed lines. The last column ( IV ) shows the mfERG 3D plots, with the full mfERG data shown in . Black arrows show the 60 Hz component. Red arrows show the fERG slow component. Green arrows show the fERG fast component. Orange arrows show the rsERG 90 Hz fast component. The r 2 value between the normal and pathological rsERG frequency spectrums are shown on the bottom left corner of each figure. All r 2 values were significant ( p < 0.05).

Article Snippet: The background light intensities used were of 0, 1, 20 and 30 cd m −2 (white light) in light-adapted conditions, and of 0, 0.0005, 0.001, 0.005, 0.05, and 1 cd m −2 (Rod-color light from Diagnosys LLC, Lowell, MA, made from the green and blue LEDs) in dark-adapted conditions.

Techniques: